Determination of Mesalamine Related Impurities from Drug Product by Reversed Phase Validated UPLC Method

A validated UPLC method for the determination of process- related impurities in Antimigraine bulk drug

An UPLC method has been developed and subsequently validated for the determination of antimigraine drug and its process-related impurities. Separation was achieved with Halo C18, 50x 4.6 mm, 2.7μm column and 1.36 g ofmonobasic potassium phosphate in 1000 mL of water with 2 mL of triethylamine at pH 6.8 using H3PO4, acetonitrile and methanol in the ratio of 55 : 38 : 7 as eluent in isocratic mod...

A validated stability-indicating UPLC method for the determination of impurities in Maraviroc.

Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class, which is used in the treatment of HIV. Maraviroc has six impurities. A novel, stability-indicating reversed-phase ultra-performance liquid chromatography (RP-UPLC) method has been developed for the quantitative determination of maraviroc in active pharmaceutical ingredients, along with its six impurities. The method is a...

A validated stability-indicative UPLC method for nilotinib hydrochloride for the determination of process-related and degradation impurities.

A novel stability-indicating ultra performance liquid chromatographic (UPLC) method has been developed for quantitative determination of nilotinib hydrochloride in active pharmaceutical ingredients along with four impurities (imp-1, imp-2, imp-3 and imp-4). The method is applicable to the quantification of related compounds and assay of nilotinib hydrochloride drug. Efficient chromatographic se...

Chapter - 4 Determination of mesalamine assay by UPLC

A Validated Reversed Phase-High Performance Liquid Chromatographic (RP-HPLC) Method for Simultaneous Estimation of Aceclofenac Drug Substance and Its Related Traces Impurities In The Solid Dosage Form

A reversed-phase high performance liquid chromatographic method is developed and validated for the simultaneous evaluation of aceclofenac and its related impurities in tablet dosage form. The chromatographic separation achieved on a C18 Inertsil reversed-phase column using an isocratic elution, being mobile phase acetonitrile: methanol: water (60:28:12) and pH of final mobile phase was adjusted...